发明名称 |
A COMPOSITION COMPRISING LERCANIDIPINE AND AN AMOUNT OF A COLLOIDAL SILICON DIOXIDE FROM 5% TO 25% BY WEIGHT TO ENHANCE BIOAVAILABILTY AND/OR SOLUBILITY |
摘要 |
Disclosed is a pharmaceutical composition adapted for oral administration comprising Lercanidipine or a pharmaceutically acceptable salt, or polymorph thereof, as an active ingredient, and an amount of a colloidal silicon dioxide 5 from 5% to 25 % by weight to enhance bioavailability and/or improve solubility, wherein the composition further comprises a binder which is present in an amount of from 5% to 20% by weight and a disintegrant which is present in an amount of from 5% to 15% by weight.
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申请公布号 |
NZ582690(A) |
申请公布日期 |
2011.12.22 |
申请号 |
NZ20080582690 |
申请日期 |
2008.07.23 |
申请人 |
PHARMATHEN SA;RECORDATI IRELAND LIMITED |
发明人 |
KARAVAS, EVANGELOS;KOUTRIS, MAKIS;SAMARA, VICKY;MATSINGOU, CHRISTINA;ILIOPOULOU, ATHINA |
分类号 |
A61K9/20;A61K31/4422 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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