发明名称 |
REVERSE GENETICS OF NEGATIVE-STRAND RNA VIRUSES IN YEAST |
摘要 |
The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA viruses in yeast, especially in budding yeast. Accordingly, the patent application relates to a recombinant yeast strain suitable for the rescue of infectious non-segmented negative-strand RNA virus particles or infectious virus-like particles. The invention also relates to the use of the recombinant yeast to prepare vaccine seed and to the use of the produced RNPs or RNPs-like to prepare vaccine formulations. It also concerns the use of the recombinant yeast for the screening of libraries of DNA.
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申请公布号 |
US2011311581(A1) |
申请公布日期 |
2011.12.22 |
申请号 |
US20090865567 |
申请日期 |
2009.01.30 |
申请人 |
MILED CHAOUKI;TANGY FREDERIC;JACOB YVES;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT PASTEUR |
发明人 |
MILED CHAOUKI;TANGY FREDERIC;JACOB YVES |
分类号 |
A61K39/12;A61P37/02;C07K14/08;C12N1/19;C12N15/63;C12P21/00;C12Q1/02 |
主分类号 |
A61K39/12 |
代理机构 |
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地址 |
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