发明名称 |
HAIR FOLLICLE NEOGENESIS |
摘要 |
<p>This invention provides a skin substitute comprising epithelial cells and modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells, and methods for using the same. This invention also provides a method for transplanting cells capable of inducing hair follicles, comprising subdermally or intradermally delivering to a patient modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells.</p> |
申请公布号 |
WO2011160055(A2) |
申请公布日期 |
2011.12.22 |
申请号 |
WO2011US40937 |
申请日期 |
2011.06.17 |
申请人 |
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.;DARLING, THOMAS, N.;LI, SHAOWEI;THANGAPAZHAM, RAJESH |
发明人 |
DARLING, THOMAS, N.;LI, SHAOWEI;THANGAPAZHAM, RAJESH |
分类号 |
C12N5/071;A61F2/10;A61K35/36;C12N5/077;C12Q1/68 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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