发明名称 |
MODIFIED PARVOVIRUS HAVING ENHANCED ANTI-TUMOUR EFFICACY |
摘要 |
Described are parvovirus variants derived, e.g., from H-1PV, showing higher anti-tumour potential compared to the wild type parvovirus, wherein said variant is characterized by (a) an amino acid substitution, alteration or addition, preferably substitution at position Lys96 of NS-2 and/or position Leu103 of NS-2 (together with a amino acid substituion at position Tyr595 of NS-1 in the latter case), or (b) an in-frame deletion in the parvovirus genome, preferably a deletion resulting in a large amino acid deletion in both the central part (aa 96-133) of NS-2 and the C-terminal part (aa 587-624) of NS-1. The present invention also relates to the use of said parvovirus variants for cancer therapy. |
申请公布号 |
CA2802599(A1) |
申请公布日期 |
2011.12.22 |
申请号 |
CA20112802599 |
申请日期 |
2011.06.17 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM |
发明人 |
SALOME, NATHALIE;DINSART, CHRISTIANE;MICHEL, NADINE;ROMMELAERE, JEAN |
分类号 |
C12N7/00;A61K35/76;A61K39/23;A61K48/00;C07K14/015;C07K16/08;C12N5/10;C12N15/86;C12N15/864 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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