发明名称 |
PERIPHERAL ADMINISTRATION OF PROTEINS INCLUDING TGF-BETA SUPERFAMILY MEMBERS FOR SYSTEMIC TREATMENT OF DISORDERS AND DISEASE |
摘要 |
<p>The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-βsuperfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent.</p> |
申请公布号 |
EP2396025(A2) |
申请公布日期 |
2011.12.21 |
申请号 |
EP20100705489 |
申请日期 |
2010.02.12 |
申请人 |
STRYKER CORPORATION |
发明人 |
GOAD, MARY ELIZABETH, PECQUET;HASKELL, MELISSA, M.;SCHRIER, DENIS;WOOD, SUSAN, A. |
分类号 |
A61K38/18;A61K9/00 |
主分类号 |
A61K38/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|