发明名称 |
SYSTEMS AND METHODS FOR MODEL-BASED qPCR |
摘要 |
A method for determining a cycle threshold for a PCR amplification curve is provided. The method includes receiving a data set for a plurality of biological samples for a PCR amplification reaction. The data set includes a plurality of amplification curves, each amplification curve associated with a biological sample of the plurality of biological samples. The method further includes performing a nonlinear optimization comprising a fit of each amplification curve to a complementary modeled amplification curve to determine a best-fit set of parameters for a modeled efficiency curve and associated amplification curve. The modeled amplification curve is based on a modeled efficiency curve. The method includes determining a cycle threshold value for each biological sample based on a complementary relationship of the modeled efficiency curve to the modeled amplification curve. In an embodiment, the nonlinear optimization is a constrained nonlinear optimization. |
申请公布号 |
WO2011130184(A3) |
申请公布日期 |
2011.12.22 |
申请号 |
WO2011US31988 |
申请日期 |
2011.04.11 |
申请人 |
LIFE TECHNOLOGIES CORPORATION;GEORGE, WALLACE R. |
发明人 |
GEORGE, WALLACE R. |
分类号 |
G06F19/12;C12Q1/68;G01N33/50;G06F17/50;G06F19/28 |
主分类号 |
G06F19/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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