| 摘要 |
The present invention relates to a process for the preparation of ²-amino acids and derivatives thereof, which is especially suited for gliptins and particularly sitagliptin. A key step makes use of suitably derivatized epoxides or aziridines, which owing to a chirality provides a source of chirality for intermediates which are suitable for building up ²-amino acids and similar compounds, in particular in the construction of the sitagliptin molecule.
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