发明名称 |
CONCISE SYNTHESIS OF LICOCHALCONE A THROUGH WATER-ACCELERATED [3,3]-SIGMATROPIC REARRANGEMENT REACTION |
摘要 |
PURPOSE: A simple synthesizing method of licochalcone A is provided to use a water-acceleration [3,3]-sigmatropic transition reaction only without [1,3]-sigmatropic and deprenylation reactions. CONSTITUTION: A simple synthesizing method of licochalcone A marked with chemical formula 6 using 4-hydroxy-2-methoxybenzaldehyde marked with chemical formula 1 comprises a step of producing protected chalcone marked with chemical formula 4, using the claisen-Schmidt condensation reaction marked with chemical formula 2 and 3. In the chemical formula 3 and 4, R is a compound selected from alkyl or silyl. The alkyl is selected from methyl, benzyl, tetrahydropyranyl, methoxymethyl, or ethoxymethyl. The silyl is t-buthyldimethylsilyl or trimethylsilyl.
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申请公布号 |
KR20110136390(A) |
申请公布日期 |
2011.12.21 |
申请号 |
KR20100056359 |
申请日期 |
2010.06.15 |
申请人 |
INDUSTRY ACADEMIC COOPERATION FOUNDATION, HALLYM UNIVERSITY |
发明人 |
JUN, JONG GAB;JEON, JAE HO |
分类号 |
C07C45/42;A61K31/12;A61P35/00;C07C49/84 |
主分类号 |
C07C45/42 |
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