发明名称 |
INFLUENZA VACCINES WITH REDUCED AMOUNTS OF SQUALENE |
摘要 |
Influenza vaccines include hemagglutinin from at least one influenza A virus strain and at least one influenza B virus strain. They also include an oil-in-water emulsion adjuvant with submicron oil droplets, comprising squalene. In some embodiments the hemagglutinin concentration is >12 μg/ml per strain. In some embodiments the squalene concentration is <19 mg/ml. In some embodiments the vaccine is mercury-free. In some embodiments the vaccine has a unit dose volume between 0.2-0.3 mL. In some embodiments the squalene concentration is 9.75 mg/mL or 4.88 mg/mL. In some embodiments the vaccine includes antigens from two influenza A virus strains and two influenza B virus strains. |
申请公布号 |
EP2396032(A2) |
申请公布日期 |
2011.12.21 |
申请号 |
EP20100710427 |
申请日期 |
2010.02.10 |
申请人 |
NOVARTIS AG |
发明人 |
CONTORNI, MARIO;O'HAGAN, DEREK;GROTH, NICOLA |
分类号 |
A61K39/145;A61K39/295;A61P31/16 |
主分类号 |
A61K39/145 |
代理机构 |
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