| 摘要 |
The present invention relates to diarylhydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
wherein R 1 and R 2 together comprise eight or fewer carbon atoms and are selected from the group consisting of alkyl, substituted alkyl, and, together with the carbon to which they are linked, a cycloalkyl or substituted cycloalkyl group,
wherein R 3 is selected from the group consisting of
, and formyl,
wherein R 4 is selected from the group consisting of hydrogen, F, Cl, Br, and I, and
wherein R 11 and R 12 are independently selected from the group consisting of hydrogen and methyl. |
