发明名称 |
IgG-Fc FRAGMENT AND PROCESS FOR PRODUCING SAME |
摘要 |
<p>Disclosed is a full-length IgG-Fc fragment having a substantially homogeneous sugar chain added thereto. Also disclosed is a process for producing the full-length IgG-Fc fragment. Specifically disclosed is an IgG-Fc fragment having a sugar chain added thereto, in which the sugar chain is added to the same position as that in a naturally occurring IgG-Fc fragment, any one amino acid residue selected from 1 st to 30 th amino acid residues from the sugar chain-added amino acid residue on the N-terminal side of the sugar chain-added amino acid residue is substituted by a Cys residue and at least one Met residue is substituted by an amino acid residue other than a Met residue. Also specifically disclosed is a process for producing the IgG-Fc fragment.</p> |
申请公布号 |
EP2397544(A1) |
申请公布日期 |
2011.12.21 |
申请号 |
EP20100741220 |
申请日期 |
2010.02.09 |
申请人 |
OTSUKA CHEMICAL CO., LTD. |
发明人 |
KAJIHARA, YASUHIRO;FUKAE, KAZUHIRO |
分类号 |
C12N15/09;C07K1/04;C07K1/113;C07K16/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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