发明名称 |
MICROCRYSTALS OF (E)-8-(3,4-DIMETHOXYSTYRYL)-1,3-DIETHYL-7-METHYLXANTHINE |
摘要 |
Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 µm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 µm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.
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申请公布号 |
CA2525037(C) |
申请公布日期 |
2011.12.20 |
申请号 |
CA20042525037 |
申请日期 |
2004.05.07 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
KURODA, KAZUTOSHI;AOKI, NOBORU;OCHIAI, TOSHIRO;UCHIDA, AKIHIRO;ISHIKAWA, YASUHIRO;KIGOSHI, MAKOTO;HAYAKAWA, EIJI;ASANOME, KAZUKI |
分类号 |
C07D473/06;A61K31/522;A61P11/06;A61P19/10;A61P25/16;A61P25/24;A61P25/28;A61P43/00 |
主分类号 |
C07D473/06 |
代理机构 |
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代理人 |
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