发明名称 |
Human monoclonal antibodies to activin receptor-like kinase-1 |
摘要 |
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention. |
申请公布号 |
US8080646(B2) |
申请公布日期 |
2011.12.20 |
申请号 |
US20090402854 |
申请日期 |
2009.03.12 |
申请人 |
NORTH MICHAEL AIDAN;AMUNDSON KARIN KRISTINA;BEDIAN VAHE;BELOUSKI SHELLY SIMS;HU-LOWE DANA DAN;JIANG XIN;KARLICEK SHANNON MARIE;KELLERMAN SIRID AIMEE;THOMSON JAMES ARTHUR;WANG JIANYING;WICKMAN GRANT RAYMOND;ZHANG JINGCHUAN;AMGEN FREMONT, INC.;PFIZER INC. |
发明人 |
NORTH MICHAEL AIDAN;AMUNDSON KARIN KRISTINA;BEDIAN VAHE;BELOUSKI SHELLY SIMS;HU-LOWE DANA DAN;JIANG XIN;KARLICEK SHANNON MARIE;KELLERMAN SIRID AIMEE;THOMSON JAMES ARTHUR;WANG JIANYING;WICKMAN GRANT RAYMOND;ZHANG JINGCHUAN |
分类号 |
C07H21/04;C12N5/10;C12N15/74 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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