Use of new or known 4-carboxy-2-pyrrolidinone derivatives in composition comprising, in medium, liquid fatty phase and lipophilic active agent, as solvent and as agent improving solubility of active agent, in liquid fatty phase

摘要

Use of 4-carboxy-2-pyrrolidinone derivatives (I) and their salts, optical isomers, stereoisomers, enantiomers, diastereomers, or any of their geometric isomers, in a composition comprising, in a medium, at least one liquid fatty phase and at least one lipophilic active agent, as solvent in the liquid fatty phase and/or as an agent improving the solubility of the active agent in the fatty phase, is claimed. Use of 4-carboxy-2-pyrrolidinone derivatives (I) or their salts, optical isomers, stereoisomers, enantiomers and diastereomers, or any of their geometric isomers in a composition comprising, in a medium, at least one liquid fatty phase and at least one lipophilic active agent, as solvent in the liquid fatty phase and/or as an agent improving the solubility of the active in the fatty phase, is claimed. R1 : 1-20C alkyl; R2 : linear 1-20C alkyl, branched 3-20C alkyl containing 5-6C ring, 5-6C cycloalkyl (optionally substituted with 1 or 2 methyl), phenyl, benzyl or phenethyl; and R3, R4 : 1-12C linear alkyl or 3-12C branched alkyl or H. Provided that R3 and R4 can not simultaneously denote H. Independent claims are included for: (1) the 4-carboxy-2-pyrrolidinone derivatives (I), where (I) excludes 2-methyl-5-oxo-1-pentyl-pyrrolidine-3-carboxylic acid ethyl ester and 1,4-dimethyl-5-oxo-pyrrolidine-3-carboxylic acid ethyl ester; and (2) the composition comprising liquid fatty phase containing at least one ester derivative of (I) and at least one lipophilic active agent, in a medium. [Image] ACTIVITY : Dermatological; Antiseborrheic. MECHANISM OF ACTION : None given.