CONJUGATES OF FLU VIRUS M2 OR HA2 FRAGMENTS AND PROTEIN CARRIERS, AND PHARMACEUTICAL USE THEREOF

摘要

Provided are a conjugate of fragments of the extracellular domain of flu virus M2 protein and protein carriers as well as a conjugate of fragments of amino acids 18-72 of flu virus HA2 protein and protein carriers. The fragments and carriers are linked covalently via disulfide bonds. Also provided are vaccines comprising the conjugates. The vaccines are suitable for large scale preparation.