VERBESSERTER HERSTELLUNGSPROZESS FÜR NEBIVOLOL- HYDROCHOLORID
摘要
<p>The present invention provides an improved process for the synthesis of Nebivolol and its pharmaceutically acceptable salts, more particularly hydrochloride salt of formula (I). Invention involves one pot synthesis of Nebivolol from epoxy monomer, which proceeds stereo specifically in high yield, without isolation of benzylated Nebivolol intermediate or its purification and does not require an additional purification of final compound.</p>