发明名称 |
Method for Producing Optically Active Fluorinated Oxetane |
摘要 |
Disclosed is a method of producing an optically active fluorinated oxetane, which can be an important pharmaceutical or agricultural intermediate, by reaction of a fluorinated α-keto ester with an acyl alkenyl ether in the presence of a transition metal complex with an optically active ligand. This method utilizes a catalytic asymmetric synthesis process and does not require a stoichiometric amount of chiral source. It is thus possible to dramatically reduce the amount of use of the asymmetric catalyst especially when the reaction is performed at a high concentration of substrate (with the use of a small amount of reaction solvent) or in the absence of a reaction solvent (under neat conditions). Further, the target optically active fluorinated oxetane can be obtained with high yield and with very high optical purity. The product contains almost no difficult-to-separate impurity and shows high chemical purity. |
申请公布号 |
US2011306781(A1) |
申请公布日期 |
2011.12.15 |
申请号 |
US201013201171 |
申请日期 |
2010.02.22 |
申请人 |
MIKAMI KOICHI;AIKAWA KOHSUKE;AIDA JUNPEI;ISHII AKIHIRO;KATO MISUGI;MASUDA TAKASHI;CENTRAL GLASS COMPANY, LIMITED;TOKYO INSTITUTE OF TECHNOLOGY |
发明人 |
MIKAMI KOICHI;AIKAWA KOHSUKE;AIDA JUNPEI;ISHII AKIHIRO;KATO MISUGI;MASUDA TAKASHI |
分类号 |
C07D305/08 |
主分类号 |
C07D305/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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