PHARMACEUTICAL PREPARATION COMPRISING MICRO-RNA-143 DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To provide a benzene-pyridine derivative of micro-RNA-143 less susceptible to degradation by a degrading enzyme (RNase) and a pharmaceutical use thereof.

SOLUTION: The micro-RNA-143 is matched at two positions of 3' terminal of antisense strand among mismatch sequences of four positions of micro-RNA-143, modified with benzene-pyridine (BP) at 3' terminal and is less susceptible to degradation by a degrading enzyme (RNase). The therapeutic agent for digestive system cancer contains the micro-RNA-143.

COPYRIGHT: (C)2012,JPO&INPIT