| 发明名称 |
MUTANT INTERLEUKIN-2 (IL-2) POLYPEPTIDES |
| 摘要 |
The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα. |
| 申请公布号 |
US2011306752(A1) |
申请公布日期 |
2011.12.15 |
| 申请号 |
US201113088045 |
申请日期 |
2011.04.15 |
| 申请人 |
WITTRUP KARL DANE;RAO BALAJI M.;LAUFFENBURGER DOUGLAS A.;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
WITTRUP KARL DANE;RAO BALAJI M.;LAUFFENBURGER DOUGLAS A. |
| 分类号 |
C07K14/55;A61K;A61K38/20;C07H21/04;C12P21/04 |
主分类号 |
C07K14/55 |
| 代理机构 |
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