COMPOUND SCREENING BASED ON SEBUM COMPOSITION

摘要

It is discovered that an agent, such as a PPAR gamma ligand or a sterol O-acyltransferase (SOAT) modulator, resulted in changes of sebum compositions in individuals administered with the agent. A signature sebum profile for the agent can be detected by a statistical clustering analysis, such as a principal component analysis (PCA), of chromatograms obtained from chromatographic analyses of sebum samples from individuals exposed to the agent. Compound screening methods based on sebum compositions are described.