发明名称 |
TUMOR TARGETED DELIVERY OF IMMUNOMODULATORS BY NANOPLYMERS |
摘要 |
Nanoconstructs having three components: (1) biodegradable nanopolymers and nanoparticles, (2) immunodrugs such as CpG, and a (3) tumor binding device, which are actively targeted to tumor cells such as melanoma cells through receptor-mediated uptake and methods of using the same are described. Antitumor immunity is further enhanced by combination of PG-CpG nanoconstructs with agonists of positive costimulatory signals and inhibitors of negative immune regulatory signals. |
申请公布号 |
WO2011097384(A3) |
申请公布日期 |
2011.12.15 |
申请号 |
WO2011US23609 |
申请日期 |
2011.02.03 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;ZHOU, DAPENG;CHUN, LI;HWU, PATRICK |
发明人 |
ZHOU, DAPENG;CHUN, LI;HWU, PATRICK |
分类号 |
A61K47/48;A61K9/127;A61K9/48;A61K39/395;A61K47/30;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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