| 摘要 |
<p>Provided herein are monoclonal antibodies or antigen-binding fragments thereof that bind to human GM-CSF or a fragment thereof, the antibodies comprise variable light chain CDR1 and CDR2 sequences as set forth in SEQ ID NOs: 43 and 44, respectively, variable heavy chain CDR1 and CDR2 sequences as set forth in SEQ ID NOs: 46 and 47, respectively and a variable light chain region CDR3 comprising the sequence as set forth in SEQ ID NO:45 with one or two amino acid substitutions therein; and/or a variable heavy chain region CDR3 comprising the sequence as set forth in SEQ ID NO:48 with one or two amino acid substitutions therein</p> |
