发明名称 |
SIALIC ACID (?-(2?6)-D-AMINOPYRANOSE DERIVATIVES, SYNTHESIS METHODS AND USES THEREOF |
摘要 |
N-acyl modified sialic acid (a-(2?6)-D-aminopyranose derivatives, their synthesis methods and uses are disclosed. Sialic acid (a-(2?6)-D-aminopyranose derivatives represented by formula (I) are synthesized by using D-aminogalactose (glucose) and sialic acid as raw materials, which are coupled with carrier proteins or polypeptides to obtain glycoprotein (glycopeptide) conjugates. Acetyl is replaced by derivative acyl in the structures of said compounds, therefore the compounds show good activity in antitumor vaccines. |
申请公布号 |
WO2011153815(A1) |
申请公布日期 |
2011.12.15 |
申请号 |
WO2011CN00610 |
申请日期 |
2011.04.08 |
申请人 |
PEKING UNIVERSITY;YE, XINSHAN;YANG, FAN;ZHENG, XIUJING |
发明人 |
YE, XINSHAN;YANG, FAN;ZHENG, XIUJING |
分类号 |
C07H5/06;A61K31/385;A61K31/7008;A61K31/7028;A61K38/02;A61P35/00;C07H1/00;C07H15/04;C07K2/00 |
主分类号 |
C07H5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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