| 发明名称 |
PROCESS FOR THE PREPARATION OF IMATINIB AND SALTS THEREOF |
| 摘要 |
Disclosed herein is a process for preparation of imatinib free base which comprises condensing 4-Methyl-N-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine with 4-(4-Methyl-piperazin-1-ylmethyl)-benzoic acid ester in the presence of base including organic bases and inorganic bases in an organic solvent to form imatinib. |
| 申请公布号 |
US2011306763(A1) |
申请公布日期 |
2011.12.15 |
| 申请号 |
US201013203141 |
申请日期 |
2010.11.18 |
| 申请人 |
KAMATH AJIT ANNU;PAI GANESH GURPUR;UJAGARE ASHISH MOHAN;HE XIAO;WU SHAOHONG;SHEN XIN;YANG JIDONG;ZHAN HUAXING;SHANGHAI PARLING PHARMATECH CO., LTD.;ARCH PHARMALABS LIMITED |
发明人 |
KAMATH AJIT ANNU;PAI GANESH GURPUR;UJAGARE ASHISH MOHAN;HE XIAO;WU SHAOHONG;SHEN XIN;YANG JIDONG;ZHAN HUAXING |
| 分类号 |
C07D401/14 |
主分类号 |
C07D401/14 |
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