Compositions and methods for modulating immune responses

摘要

The present invention provides a newly identified B7 receptor, zB7Rl that functions as lymphocyte inhibitory receptor, which is a PD-I -like molecule and is expressed on T cells. The present invention also provides the discovery of zB7Rl's ability to bind to CD155. Methods and compositions for modulating zB7Rl -mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.