发明名称 |
METHOD OF SYNTHESIS OF FERROQUINE BY CONVERGENT REDUCTIVE AMINATION |
摘要 |
The invention relates to a method of synthesis of ferroquine of formula (F) or of its metabolite of formula (Fm): comprising a reaction of reductive amination, said reaction comprising: (i) a stage of condensation of the aldhehyde-amino ferrocene of formula (1 ), which R represents a hydrogen atom or a methyl group, with the 7-chloroquinolin- amine of formula (2) as shown below, followed by (ii) a stage of reduction of the product of condensation obtained in the preceding stage (iii) then a stage of hydrolysis of the reaction mixture in the presence of an aqueous solution of ammonia or of citric acid.
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申请公布号 |
CA2802161(A1) |
申请公布日期 |
2011.12.15 |
申请号 |
CA20112802161 |
申请日期 |
2011.06.10 |
申请人 |
SANOFI |
发明人 |
FEREY, VINCENT;MATEOS-CARO, JULIA;MONDIERE, REGIS;VAYRON, PHILIPPE;VIGNE, SYLVIE |
分类号 |
C07F17/02 |
主分类号 |
C07F17/02 |
代理机构 |
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代理人 |
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