发明名称 |
Antibodies against nerve growth factor (NGF) with enhanced in vivo stability |
摘要 |
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided. |
申请公布号 |
AU2010244133(A1) |
申请公布日期 |
2011.12.15 |
申请号 |
AU20100244133 |
申请日期 |
2010.05.04 |
申请人 |
ABBOTT RESEARCH B.V. |
发明人 |
POWELL, JOHN;MAGINN, MARK;CASSON, DUNCAN;BEST, ANDREA;DUTTA, SANDEEP;HALL, JERRY A.;LIU, WEI |
分类号 |
C07K16/22;A61K39/395;A61P25/00;C12N5/10;C12N15/13 |
主分类号 |
C07K16/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|