发明名称 PRODUCTION OF FERTILE XY ANIMALS FROM XY ES CELLS
摘要 Methods and compositions are described for making phenotypically female fertile animals from XY donor cells and suitable host embryos. Culture media and methods are provided for maintaining XY donor cells in culture that after introduction into a host embryo and gestation in a suitable host will result in fertile XY female animals. Methods and compositions are described for making fertile female animals in an F0 generation from a donor XY cell and a host embryo, as are methods for making F1 progeny that are homozygous for a modification from a heterozygous F0 fertile male and a heterozygous F0 fertile female sibling.
申请公布号 US2011307968(A1) 申请公布日期 2011.12.15
申请号 US201113157728 申请日期 2011.06.10
申请人 AUERBACH WOJTEK;DECHIARA THOMAS;POUEYMIROU WILLIAM;FRENDEWEY DAVID;VALENZUELA DAVID;REGENERON PHARMACEUTICALS, INC. 发明人 AUERBACH WOJTEK;DECHIARA THOMAS;POUEYMIROU WILLIAM;FRENDEWEY DAVID;VALENZUELA DAVID
分类号 A01K67/027;A01K67/02;C12N15/873 主分类号 A01K67/027
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