摘要 |
<p>The present invention relates to a tumor marker or group of tumor markers associated with the progression of a neoplastic disease from a less progressed stage to a more progressed stage, wherein the expression of the tumor markers is modified when comparing the expression in the less progressed stage and in the more progressed stage. The present invention further relates to a composition for diagnosing, detecting, graduating, monitoring or prognosticating a neoplastic disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage comprising affinity ligands for the expression products of the tumor markers, to corresponding methods, and to the use of said tumor markers for detecting, diagnosing, graduating, monitoring or prognosticating a neoplastic disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage. The present invention further relates to a corresponding immunoassay, to a method of identifying an individual for eligibility for a neoplastic disease therapy, as well as to a pharmaceutical composition based on the inhibition and/or activation of the expression of said tumor markers.</p> |
申请人 |
KONINKLIJKE PHILIPS ELECTRONICS N.V.;HOFFMANN, RALF;ROMIJN, EDWIN, P.;VISSER, HUGO, M.;HULSEN, TIM |
发明人 |
HOFFMANN, RALF;ROMIJN, EDWIN, P.;VISSER, HUGO, M.;HULSEN, TIM |