DEACETYLATION HYDROLASE OF HYALURONIC ACID, HYALURONIC ACID DEACETYLATED BY SAME AND DERIVATIVE THEREOF

摘要

The present invention relates to a deacetylation hydrolase of a hyaluronic acid, a hyaluronic acid deacetylated by same and a derivative thereof. The deacetylated hyaluronic acid and the derivative thereof of the present invention have the following characteristics: a delayed initial decomposition rate on a living body; minimized decrease of molecular weight and viscosity; accelerated gelatinization due to a lower gelatinization temperature than the gelatinization temperature for a non-deacetylated hyaluronic acid; and an hMSC survival rate that is hardly affected by increased concentration of the deacetylated hyaluronic acid and the derivative thereof in a culture medium. As a result, the deacetylated hyaluronic acid and the derivative thereof of the present invention can be useful as a bioingredient such as a delivery system for a cell, gene, drug, and the like, or a support for tissue engineering, etc.