INDUCTION OF BONE FORMATION

摘要

This invention relates to a method of inducing epidural bone formation in a mammal, to a substantially fluid impermeable physical barrier for use said method of inducing epidural bone formation in a mammal and a kit for use in inducing epidural bone formation at a desired location in a mammalian body. The method involves positioning, over the dural area of a mammalian body where bone induction is desired, a substantially fluid impermeable physical barrier and introducing, into the area between the dura and existing bony tissue where bone formation is desired, a transforming growth factor-ß isoform. The barrier is, preferably, a synthetic plastics material membrane and the transforming growth factor-ß isoform is TGF-ß3 which is used in conjunction with a suitable substrate.