发明名称 |
PRODUCTION OF AN HOMOGENEOUS VACCINE PREPARATION FOR CANCER TREATMENT |
摘要 |
<p>Summary of the Invention: The present invention relates to the biotechnological field and particularly to the human health. More particularly, the present invention relates to a vaccine composition for therapeutic use in cancer patients. The vaccine composition of the present invention has as active principle a chemical conjugated between the human recombinant Epidermal Growth Factor (hrEGF) and the P64K recombinant protein. In another embodiment, the present invention relates to the conjugation procedure to obtain, a chemical conjugated under controlled and reproducible parameters. In a preferred embodiment, the present invention relates to the procedure for purifying the chemical conjugated with a higher purity of the therapeutical vaccine composition, and a surprisingly increased immunogenic activity, inducing a significant increase of the anti-EGF antibody titers in humans. Additionally the present invention provides the methodology to obtain a vaccine composition in several dose presentations (total milligrams of conjugated EGF-P64K/vial). The versatility of the dose presentation allows increasing the immunization dose per patient, without increasing the frequency of injections and / or immunization sites. Besides, the present invention relates to a sanitary procedure for obtaining a vaccine composition for parenteral route in the cancer therap.</p> |
申请公布号 |
EP2184072(B1) |
申请公布日期 |
2011.12.14 |
申请号 |
EP20080757902 |
申请日期 |
2008.06.26 |
申请人 |
CENTRO DE INMUNOLOGIA MOLECULAR |
发明人 |
RODRIGUEZ MARTINEZ, GRYSSELL MARIA;VINA RODRIGUEZ, LISEL;CALVO GONZALEZ, LOANY;CUEVAS FIALLO, ARIADNA;CHICO VELIZ, ERNESTO;CROMBET RAMOS, TANIA;ALBISA NOVO, AIRAMA;GONZALEZ MARINELLO, GISELA MARIA;LAGE DAVILA, AGUSTIN BIENVENIDO |
分类号 |
A61K39/385 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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地址 |
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