| 摘要 |
PURPOSE: A short chain insulin analog complex is provided to ensure insulin-like activity in vivo and to prevent low blood glucose. CONSTITUTION: A short chain insulin analog complex is linked through a non-peptide linker. The short chain insulin analog and immunoglobulin Fc region is polyethylene glycol, polypropylene glycol, ethylene glycol-propylene glycol copolymer, polyoxyethylation polyol, polyvinyl alcohol, polysaccharide, dextran, polyvinyl ethyl ether, biocompatible polymers, lipid polymers, chitins, hyaluronic acid, or mixture thereof. The immunoglobulin Fc region has CH1, CH2, CH3 or CH4 domain and additionally contains hinge domain.
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