发明名称 |
Method for determining immunostimulatory activity of RNA oligonucleotides |
摘要 |
The present invention provides 4-nucleotide (4mer) RNA motifs that confer immunostimulatory activity, in particular, IFN-α-inducing activity to a RNA oligonucleotide. The present invention also provides RNA oligonucleotides, including siRNA, with high or low immunostimulatory activity. The present invention further provides the use of the RNA oligonucleotides of the invention for therapeutic purposes. |
申请公布号 |
US8076068(B2) |
申请公布日期 |
2011.12.13 |
申请号 |
US20060066903 |
申请日期 |
2006.09.14 |
申请人 |
HARTMANN GUNTHER;HORNUNG VEIT |
发明人 |
HARTMANN GUNTHER;HORNUNG VEIT |
分类号 |
C12Q1/68;C12N15/11;C12N15/117 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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