发明名称 |
Therapeutic agents of colivelin for neurodegenerative diseases |
摘要 |
The present invention relates to a pharmaceutical composition for the treatment and/or prevention of a neurodegenerative disease, comprising the following polypeptide shown in any of (a) to (c): (a) a polypeptide comprising the amino acid sequence represented by Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO: 1); (b) a polypeptide comprising an amino acid sequence having a deletion, substitution, insertion, and/or addition of one or several amino acids in the amino acid sequence consisting of Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO: 1), and having an activity that inhibits neuronal cell death associated with neurodegenerative disease; and (c) a modified polypeptide from the polypeptide (a) or (b), or a pharmaceutically acceptable salt thereof, as an effective ingredient. |
申请公布号 |
US8076449(B2) |
申请公布日期 |
2011.12.13 |
申请号 |
US20050578142 |
申请日期 |
2005.04.08 |
申请人 |
CHIBA TOMOHIRO;KITA YOSHIKO;MATSUOKA MASAAKI;TERASHITA KENZO;AISO SADAKAZU;NISHIMOTO IKUO;NISHIMOTO, LEGAL REPRESENTATIVE TOMO;TOMOHIRO CHIBA;MASSAAKI MATSUOKA;KENZO TERASHITA;SADAKAZU ALSO;TOMO NISHIMOTO |
发明人 |
CHIBA TOMOHIRO;KITA YOSHIKO;MATSUOKA MASAAKI;TERASHITA KENZO;AISO SADAKAZU;NISHIMOTO IKUO;NISHIMOTO, LEGAL REPRESENTATIVE TOMO |
分类号 |
A61K38/16;A61K38/00;A61K38/08;A61K38/18;A61P25/02;A61P25/28;C07K7/06;C07K14/00;C07K14/47;C07K17/00;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12P21/02 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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