发明名称 |
Antibody and inhibitor, and transfection method or kit using them |
摘要 |
The present invention provides a monoclonal antibody which specifically binds to human Toll-like receptor 3 and inhibits production of type 1 interferon. It also provides an inhibitor which (a) suppresses a double-stranded RNA-mediated immune response in a cell which expresses Toll-like receptor 3 that recognizes the double-stranded RNA and produces type I interferon, and (b) includes an antibody, which binds to the Toll-like receptor 3 and inhibits production of the type I interferon. Particularly, the monoclonal antibody is against human Toll-like receptor 3. Further, a transfection method and kit are provided. Production of type I interferon can be controlled by using an antibody which specifically binds to Toll-like receptor 3 that recognizes a double-stranded RNA and produces type I interferon. |
申请公布号 |
US8076460(B2) |
申请公布日期 |
2011.12.13 |
申请号 |
US20080314556 |
申请日期 |
2008.12.12 |
申请人 |
MATSUMOTO MISAKO;SEYA TSUKASA;JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
MATSUMOTO MISAKO;SEYA TSUKASA |
分类号 |
C07K16/00;C12N15/09;A61K39/395;A61P31/12;C07K16/28 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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