METHODS OF PREDICTION OF DPD ENZYME ACTIVITY USING HAPLOTYPE IN KOREAN

摘要

PURPOSE: A method for predicting DPD(Dihydropyrimidine dehydrogenase) is provided to analyze genetic polymorphism of DPD and to develop a drug metabolized by DPD. CONSTITUTION: A method for analysis of Korean DPD gene haplotype comprises: a step of obtaining exon 13 and intron 13 encoding DPD from genome DNA to determine each base sequence; a step of detecting SNP in the determined each base sequence; and a step of identifying haplotype selected among Hap1 to Hap3 using the detected SNP. A method for predicting Korean DPD comprises: a step of confirming a DPD gene of a person who is tested, among Hap1 to Hap3; and a step of predicting DPD activity using the confirmed haplotype information.