| 摘要 |
FIELD: medicine. ^ SUBSTANCE: there are presented version forms of uricase containing sequences referred in the description. Also, there is presented a recovered nucleic acid containing a nucleotide sequence which codes said uricase, and said nucleic acid is operatively bound with a heterological promoter. There is described an expression vector containing said nucleic acid and a host cell containing this vector and being an uricase producer. There are described a method for producing uricase involving stages of cultivation of said host cells under conditions when the nucleic acid sequence is expressed by the host cells, and of uricase recovery. ^ EFFECT: invention allows relieving hyperuricemia and hyperuricosuria. ^ 13 cl, 8 dwg, 7 tbl, 8 ex |
