16-ALKOXY-14-ARYL-3,15-DIOXA-10-AZATETRACYCLO [8,7,0,01,13.04,9] HEPTADECA-4,6,8,13-TETRAENE-2,11,12-TRIONES AND SYNTHESIS METHODS THEREOF

摘要

FIELD: chemistry. ^ SUBSTANCE: present invention relates to novel 16-alkoxy-14-aryl-3,15-dioxa-10-azatetracyclo[8.7.0.01,13.04,9]heptadeca-4,6,8,13-tetraene-2,11,12-triones , where Alk = Et (a-c), Bu (d), Ar = Ph (a, d), C6H4Br-4(b), C6H4OMe-4(c). Such compounds are found to exhibit analgesic activity. ^ EFFECT: invention relates to methods of producing described compounds through reaction of aroylpyrrolo[2,1-c][1,4]benzoxazine-1,2,4(4H)-triones with alkyl vinyl esters while boiling in the medium of an inert aprotic solvent. ^ 3 cl, 5 ex, 1 tbl