| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, and concerns combined vaccines with a low-dose HIB conjugate. The substance of the invention includes the combined vaccines containing diphtheria, tetanus, whooping cough and HIB immunisation antigens (DTP-HIB vaccines), in which: (a) Hib protection antigen represents a capsular saccharide Hib conjugate; (b) the concentration of Hib conjugate in the vaccine makes 1.25 to less than 15 mcg/ml; and (c) Hib conjugate is never lyophilised. ^ EFFECT: production of the safe and highly immunogenic combined vaccines. ^ 17 cl, 1 dwg |
