摘要 |
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid. |
申请人 |
ALNYLAM PHARMACEUTICALS, INC.;MANOHARAN, MUTHIAH;MAIER, MARTIN;JAYARAMAN, MUTHUSAMY;MATSUDA, SHIGEO;JAYAPRAKASH, NARAYANANNAIR, K.;RAJEEV, KALLANTHOTTATHIL, G. |
发明人 |
MANOHARAN, MUTHIAH;MAIER, MARTIN;JAYARAMAN, MUTHUSAMY;MATSUDA, SHIGEO;JAYAPRAKASH, NARAYANANNAIR, K.;RAJEEV, KALLANTHOTTATHIL, G. |