There is provided a recombinant bacterium comprising at least one overexpressed acyl-ACP thioesterase gene, and wherein at least one gene from the tricarboxylic acid cycle or glycolysis or both is inactivated. There is also provided a method for producing fatty acids, said method comprising culturing bacteria comprising at least one overexpressed acyl-ACP thioesterase gene in a growth medium in a container having walls; allowing said bacteria to secrete fatty acids; and collecting said fatty acids. Acid supplementation is also shown to increase productivity.
申请公布号
WO2011116279(A3)
申请公布日期
2011.12.08
申请号
WO2011US28983
申请日期
2011.03.18
申请人
WILLIAM MARSH RICE UNIVERSITY;SAN, KA-YIU;LI, MAI;ZHANG, XIUJUN