| 摘要 |
The aim of the invention was to create biological active substances that can be transfected into or onto target cells in living beings, plants, and fungi in vitro as well as in vivo and only there inhibit the expression of genes highly effectively without affecting the target-gene expression specific to the active agent and thus the formation of proteins in other cells of the organism. According to the invention, the siRNA (1) has at least one covalent bond (6) to one or more oligosaccharides (3), which each have one or more specific chemical structures selected for enzymes typical of the target cells. By means of said bond (6), which is broken only by said enzyme or enzymes typical of the target cells in order to biologically activate the active substance, the molecules remain biologically inactive in cells other than the target cells. Said molecules are used, for example, to influence the gene expression of preferably diseased organs, cells, or plants that are infected and afflicted with parasites or fungi. |
