THERMAL DENATURATION SCREENING ASSAY TO IDENTIFY CANDIDATE COMPOUNDS FOR PREVENTION AND TREATMENT OF PARKINSON'S DISEASE
摘要
<p>Thermal Denaturation Screening Assay to Identify Candidate Compounds for Prevention and Treatment of Parkinson's Disease The invention provides highthroughput screening assays to identify agents useful for treatment of Parkinson's Disease. In one embodiment the assay includes exposing a plurality of test samples, each containing a test compound and parkin protein, to thermal destabilization conditions and determining parkin ligase activity in the test samples relative to a control sample not containing a test agent. A test agent contained in a test sample in which parkin ligase activity exceeds the ligase activity in said control sample is identified as a candidate compound for treatment of Parkinson's Disease.</p>
申请公布号
WO2009099896(A9)
申请公布日期
2011.12.08
申请号
WO2009US32473
申请日期
2009.01.29
申请人
ELAN PHARMA INTERNATIONAL LIMITED;JOHNSON, JENNIFER, A.;SZOKE, BALAZS, G.;MCCONLOGUE, LISA
发明人
JOHNSON, JENNIFER, A.;SZOKE, BALAZS, G.;MCCONLOGUE, LISA