发明名称 |
ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR |
摘要 |
<p>The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co- administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors. The immunoconjugates comprise antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells.</p> |
申请公布号 |
WO2010124797(A8) |
申请公布日期 |
2011.12.08 |
申请号 |
WO2010EP02342 |
申请日期 |
2010.04.16 |
申请人 |
BAYER PHARMA AKTIENGESELLSCHAFT;KAHNERT, ANTJE;BERHOERSTER , KERSTIN;HEISLER , IRING;KOPITZ , CHARLOTTE CHRISTINE;SCHUMACHER, JOACHIM |
发明人 |
KAHNERT, ANTJE;BERHOERSTER , KERSTIN;HEISLER , IRING;KOPITZ , CHARLOTTE CHRISTINE;SCHUMACHER, JOACHIM |
分类号 |
A61K47/48;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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