PET RADIOPHARMACEUTICALS FOR DIFFERENTIAL DIAGNOSIS BETWEEN BILATERAL AND UNILATERAL CONDITIONS OF PRIMARY HYPERALDOSTERONISM
摘要
A functional PET imaging method is disclosed for differentiation between bilateral hyperplasia and unilateral adenoma comprising (1) introducing a radioactively labelled CYP11 B2 (aldosterone synthase) inhibitor which binds selectively to CYP11 B2 (aldosterone synthase) relative to CYP11 B1 (11ß-hydroxylase) into a mammal with adrenal glands and (2) conducting positron emission tomography (PET) in the region of the adrenal glands to obtain a functional PET image of the adrenal glands. Also disclosed are radioactive tracer compounds suitable for use in this method, precursors for making the same, and a process for making the radioactive tracer compounds capable of being conducted as a rapid one-pot reaction.
申请公布号
WO2011151411(A1)
申请公布日期
2011.12.08
申请号
WO2011EP59135
申请日期
2011.06.01
申请人
JULIUS-MAXIMILIANS-UNIVERSITAET;UNIVERSITAET DES SAARLANDES;ALLOLIO, BRUNO;HAHNER, STEFANIE;SCHIRBEL, ANDREAS;HARTMANN, ROLF;ZIMMER, CHRISTINA
发明人
ALLOLIO, BRUNO;HAHNER, STEFANIE;SCHIRBEL, ANDREAS;HARTMANN, ROLF;ZIMMER, CHRISTINA