USE OF COMPOUNDS WITH THROMBOPOIETIC ACTIVITY TO PROMOTE BONE GROWTH AND HEALING
摘要
TPO was used to promote the growth of bone in both rats and in mice. Gaps in both mouse and in rat bones were treated with a scaffold sized to fit the gap. Scaffolds that included TPO promoted better outcomes than scaffolds that included BMP-2 or scaffolds that did not include either TPO or BMP-2. These data indicate that compounds that exhibit thrombopoietic activity such a recombinant TPO can be used to promote bone growth and healing in mammals.
申请公布号
WO2011153512(A2)
申请公布日期
2011.12.08
申请号
WO2011US39187
申请日期
2011.06.03
申请人
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION;KACENA, MELISSA, A.;CHU, TIEN-MIN, GABRIEL