发明名称 |
METHODS OF TREATING CANCER USING IL-21 AND MONOCLONAL ANTIBODY THERAPY |
摘要 |
Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies. |
申请公布号 |
US2011300098(A1) |
申请公布日期 |
2011.12.08 |
申请号 |
US20100826099 |
申请日期 |
2010.06.29 |
申请人 |
KINDSVOGEL WAYNE R.;HUGHES STEVEN D.;HOLLY RICHARD D.;CLEGG CHRISTOPHER H.;FOSTER DONALD C.;JOHNSON REBECCA A.;HEIPEL MARK D.;SIVAKUMAR PALLAVUR V.;ZYMOGENETICS, INC. |
发明人 |
KINDSVOGEL WAYNE R.;HUGHES STEVEN D.;HOLLY RICHARD D.;CLEGG CHRISTOPHER H.;FOSTER DONALD C.;JOHNSON REBECCA A.;HEIPEL MARK D.;SIVAKUMAR PALLAVUR V. |
分类号 |
A61K38/20;A61K39/395;A61P35/00;C07K16/28;C07K16/32 |
主分类号 |
A61K38/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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