发明名称 |
NOVEL INTERFERON-ALPHA-PRODUCING BONE MARROW DENDRITIC CELLS |
摘要 |
A novel dendritic cell type has been identified within bone marrow, termed myelos interferon dendritic cells (miDC). These novel cells possess the high IFN-alpha producing activity of pDC, but they also display a wide TLR responsiveness along with T-cell stimulation capacities that more closely resemble the conventional DC populations. Moreover, these cells appear less prone to apoptosis upon activation stimuli, including viruses. These cells constitute a novel bone marrow innate immune cell type, ideally geared to linking innate and adaptive immune responses via their potent IFN-alpha production and high T-cell stimulatory capacity. |
申请公布号 |
WO2011151078(A1) |
申请公布日期 |
2011.12.08 |
申请号 |
WO2011EP02747 |
申请日期 |
2011.06.03 |
申请人 |
BAVARIAN NORDIC A/S;O'KEEFFE, MEREDITH;HOCHREIN, HUBERTUS |
发明人 |
O'KEEFFE, MEREDITH;HOCHREIN, HUBERTUS |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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