发明名称 |
TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF |
摘要 |
The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation. |
申请公布号 |
US2011300177(A1) |
申请公布日期 |
2011.12.08 |
申请号 |
US20090420803 |
申请日期 |
2009.04.08 |
申请人 |
GIN DAVID;ADAMS MICHELLE;DENG KAI;PERL NICHOLAS;WON ANNIE;LIVINGSTON PHILIP;RAGUPATHI GOVIND |
发明人 |
GIN DAVID;ADAMS MICHELLE;DENG KAI;PERL NICHOLAS;WON ANNIE;LIVINGSTON PHILIP;RAGUPATHI GOVIND |
分类号 |
A61K39/39;A61K39/00;A61K39/002;A61K39/02;A61K39/12;A61P31/04;A61P31/12;A61P35/00;A61P37/04;C07H15/256 |
主分类号 |
A61K39/39 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|